Standard Manufacturing Procedure and Quality Control of Karpanpatru Roll-on Prepared with Coconut Oil
Introduction: Karpanpatru formulation is a formulation used since long in Gujarat Ayurved University for treating Shvitra (vitiligo). The aim of the present study was to develop standard manufacturing procedure and establish preliminary analytical profile of Karpanpatru roll on. As coconut oil is beneficial for skin and possesses emollient properties; it is used in conversion of the formulation into roll-on to assure uniform application with a target oriented approach and safe handling in view of arsenic content. Methods: Total five batches of Karpanpatru roll-on were prepared from one litre of Karpanpatru Taila for each batch. The ingredients for the formulation after procurement from different sources were authenticated and was prepared following classical guidelines of Sneha Paka and Siktha (Bees wax) was added to prepare roll-on. Organoleptic and physico-chemical analysis of the finished product was carried out to develop preliminary quality parameters. Results: For preparation of one litre of Karpanpatru Taila, an average of 5 days of intermittent heating (average 1.5 h/day) and 9.02 h duration for optimum Sneha Siddhi (completion of Karpanpatru Taila) was required. For preparation of Karpanpatru roll-on, Siktha was required in the proportion of 1/10th part of Karpanpatru Taila. Organoleptic and physico-chemical profiles of the roll-on form were established. Conclusion: Karpanpatru Taila exhibited an average loss of 10.4%. Arsenic content was found to be 33.44 ppm in the roll-on. The adopted procedure, outcomes and test results of analysis of Karpanpatru roll-on may be useful in establishing the standardization of Karpanpatru roll-on and considered as standards for future studies.