Shelf Life Evaluation of Trivrit Avaleha - A Preliminary Assessment
Introduction: Potency of drug is termed as Virya of Ausadhi (effectiveness of drug) and the time period, where it retains the potency is known as Saviryata Avadhi. Every product has definite shelf life that depends on physical, chemical, environmental and biological factors. Though, shelf life of various categories of āyurvedic medicines is available; there is a need to revalidate the shelf life of individual formulations by following parameters prevalent in respective scenario. Trivrit Avaleha is mentioned in Astanga Hridaya for Virecana (therapeutic purgation). Aim of the current study is to evaluate shelf life of Trivrit Avaleha (TA) with the help of modern analytical techniques. Methods: Physico-chemical parameters were measured at 40°C ± 2°C temperature and 75%±5% relative humidity. Analysis was repeated at intervals of 1, 3, and 6 months and average 10% degradation of the test drug samples was calculated and extrapolated to find the shelf life. Results: Product was found to be free from microbial contamination and heavy metals were within the permissible limits. There were insignificant changes in physico-chemical profiles at different intervals of analysis. On extrapolation of the observations, the shelf life of TA was found to be 1 year and 11 months. Conclusion: Shelf life of TA is found within the standards of Gazettes of Govt. of India as well as Sarandhara Samhitā.